CALCRL — Calcitonin receptor like receptor
CALCRL belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CALCRL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vasoactive GPCR Signaling Endothelial cell development | APLNR, BAIAP2L1, COPZ2, CYSLTR1, ETS2, FAM110D, FAM167B, IFI16 +10 more | View in SCUBA |
| Fibroblasts | Adventitial Fibroblast State Developmental | AKAP7, BLNK, C1QA, CACNA1G, COL21A1, CYP1B1, FAT3, KIRREL2 +9 more | View in SCUBA |
| Pericytes | Basement Membrane Maintenance ECM production | DYSF, EXOC3L1, FAM167B, GRB10, HSPG2, PPM1F, RAPGEF4, RFLNB +1 more | View in SCUBA |
About the gene
| Synonyms | CGRPR, CRLR |
|---|---|
| Chromosome | 2: 187341964-187448460 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.