SFXN3 — Sideroflexin 3
SFXN3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SFXN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T cell Identity Signaling TCR Signaling | CDC42SE1, CLIP4, ETS1, FCHSD1, H3C1, ITGA4, ITK, KHNYN +14 more | |
| Macrophages | Endolysosomal Trafficking Vesicular traficking | ANKRD10, ATP1A1, ATP6V0A1, CHFR, CHML, FAR1, FBXL5, GSAP +21 more | View in SCUBA |
About the gene
| Synonyms | SFX3, SLC56A3 |
|---|---|
| Chromosome | 10: 101031234-101041241 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins |
| Biological process | Amino-acid transport, One-carbon metabolism, Transport |
Function
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.