CDC42SE1 — CDC42 small effector 1
CDC42SE1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDC42SE1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TGF-beta/differentiation Intercellular communication | CEMIP2, ENC1, KLF3, LYST, SLC12A6, SMAD3, ST3GAL1, TSPAN3 | View in SCUBA |
| Gamma-delta T cells | T cell Identity Signaling TCR Signaling | CLIP4, ETS1, FCHSD1, H3C1, ITGA4, ITK, KHNYN, MARCHF6 +14 more | |
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CHD7, CHKA, CRYBG1 +19 more | View in SCUBA |
| Macrophages | RNA Splicing Regulation Housekeeping | ABCF1, CDC5L, CDV3, CEBPZ, DNAJC7, DYNC1LI1, FGFR1OP2, GNL3 +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA Processing Translation RNA processing & translation | ACTN4, CSDE1, DDX5, EIF4G1, GDI1, HNRNPU, MSN, NCL +7 more |
About the gene
| Synonyms | SCIP1, SPEC1 |
|---|---|
| Chromosome | 1: 151050971-151070325 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell shape, Phagocytosis |
Function
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T- cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.