H3C1 — H3 clustered histone 1
H3C1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H3C1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T cell Identity Signaling TCR Signaling | CDC42SE1, CLIP4, ETS1, FCHSD1, ITGA4, ITK, KHNYN, MARCHF6 +14 more | |
| Natural Killer cells | Inflammatory Stress Response Stress | AKIRIN2, CCNH, CEBPD, CLASP1, FKBP5, P2RX5, PARP8, PIK3IP1 +2 more | View in SCUBA |
About the gene
| Synonyms | H3/A, H3FA, HIST1H3A |
|---|---|
| Chromosome | 6: 26020451-26020958 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.