SHF — Src homology 2 domain containing F
SHF belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SHF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NFkB/MAPK activation BCR/AP1/NFKb pathway | BIRC3, CCDC107, CD72, CHI3L2, CLEC2B, DENND4A, LRRFIP1, MAP3K8 +7 more | View in SCUBA |
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2 +23 more | View in SCUBA |
About the gene
| Chromosome | 15: 45167214-45201175 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Adapter protein which may play a role in the regulation of apoptosis in response to PDGF
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.