SHPRH — SNF2 histone linker PHD RING helicase
SHPRH belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SHPRH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | Lymphocyte Survival T cell maturation | ARHGEF3, BTN3A1, CNTRL, GIMAP8, ME2, PCMTD1, PRKACB, RSBN1L +4 more |
About the gene
| Synonyms | bA545I5.2, FLJ90837, KIAA2023 |
|---|---|
| Chromosome | 6: 145864245-145964423 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, Transferase |
| Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.