Lymphocyte Survival
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
GIMAP8 is the top hub gene and a member of the GTPase immunity-associated protein (GIMAP) family, which are critical regulators of lymphocyte survival and homeostasis. BTN3A1 (butyrophilin 3A1) is directly relevant to MAIT biology as it presents phosphoantigens and participates in non-classical T cell activation. TCF12 (HEB) is an E-protein transcription factor essential for T cell development and identity maintenance. PRKACB (PKA catalytic subunit β) regulates T cell quiescence via cAMP signaling. TPR (nuclear pore scaffold), SHPRH (E3 ligase), and STX17 (autophagy SNARE) support cellular homeostasis functions.
Genes
ARHGEF3, BTN3A1, CNTRL, GIMAP8, ME2, PCMTD1, PRKACB, RSBN1L, SHPRH, STX17, TCF12, TPR, XRN1
Most correlated modules
- Epigenetic Maintenance · correlation 0.90
- Histone Modification · correlation 0.90
- Chromatin Remodeling · correlation 0.87
- TGF-β Immune Regulation · correlation 0.87
- Vesicle Membrane Trafficking · correlation 0.87
- RNA Splicing Processing · correlation 0.85
- Chromatin Epigenetic Regulation · correlation 0.85
- Oxidative Stress Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.