BTN3A1 — Butyrophilin subfamily 3 member A1
BTN3A1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BTN3A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Splicing Processing RNA processing | ANXA2R, APOL3, CCNL1, CHCHD7, CMPK1, DDX5, EIF4A2, EIF5 +7 more | View in SCUBA |
| Endothelial | MHC Class I Presentation Inflammation | B2M, BST2, BTN3A2, CYSTM1, HLA-A, HLA-B, HLA-C, HLA-F +1 more | View in SCUBA |
| Gamma-delta T cells | Butyrophilin gd Activation TCR Signaling | ABI1, ADD3, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A3 +16 more | |
| Mucosal-associated invariant T cell | Lymphocyte Survival T cell maturation | ARHGEF3, CNTRL, GIMAP8, ME2, PCMTD1, PRKACB, RSBN1L, SHPRH +4 more |
About the gene
| Synonyms | BT3.1, BTF5, BTN3.1, CD277 |
|---|---|
| Chromosome | 6: 26402237-26415208 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.