ME2 — Malic enzyme 2
ME2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ME2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Core energy metabolism Mitochondrial & OxPhos | ACAA2, CFL1, CYCS, GAPDH, P4HB, PPA1, PSME2, SOD1 | View in SCUBA |
| Gamma-delta T cells | Proteostasis/Chaperonin Protein processing & ER | BST2, CARD16, CBR1, CCT3, CCT6A, DOK2, DYNLL1, HIKESHI +13 more | |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Survival T cell maturation | ARHGEF3, BTN3A1, CNTRL, GIMAP8, PCMTD1, PRKACB, RSBN1L, SHPRH +4 more |
About the gene
| Chromosome | 18: 50879080-50954257 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Oxidoreductase |
Function
NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.