SIN3B — SIN3 transcription regulator family member B
SIN3B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIN3B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Cell Migration migration & adhesion | CISD1, CTHRC1, GALNT1, MARCKS, MARCKSL1, NARF, PHLDB2, RHOJ +5 more | View in SCUBA |
| Gamma-delta T cells | SR Kinase & RNA RNA processing & translation | ADHFE1, ATF2, BCAP31, C4orf3, CCPG1, CHKB, CLK2, EFR3A +17 more |
About the gene
| Synonyms | KIAA0700 |
|---|---|
| Chromosome | 19: 16829398-16880353 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.