Endothelial Cell Migration
Gene co-expression module in Endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include MARCKS and MARCKSL1 (myristoylated alanine-rich C-kinase substrates, actin cytoskeleton/cell migration regulators), RHOJ (Rho GTPase expressed in endothelial cells, regulates cell migration and tube formation), PHLDB2 (pleckstrin homology-like domain, cell migration), SHC1 (adaptor for growth factor receptor signaling/migration), CTHRC1 (collagen triple helix repeat, ECM/migration), TIMP1 (tissue inhibitor of metalloproteinase), GALNT1 (O-glycosylation). The module is strongly upregulated in inflammation and reverses in remission. MARCKS/MARCKSL1 and RHOJ are well-established endothelial migration regulators. This module represents an endothelial cell migration and cytoskeletal remodeling program activated during inflammation.
Genes
CISD1, CTHRC1, GALNT1, MARCKS, MARCKSL1, NARF, PHLDB2, RHOJ, SHC1, SIN3B, SOX4, SPSB1, TIMP1, UBTD1
Most correlated modules
- Inflammatory Stress Response · correlation 0.84
- Redox Stress Response · correlation 0.83
- p53 Stress Response · correlation 0.82
- Lysosomal Autophagy Program · correlation 0.76
- Inflammatory Endothelial Activation · correlation 0.76
- Angiogenic Metabolic Adaptation · correlation 0.74
- Inflammatory EC Activation · correlation 0.74
- Oxidative Phosphorylation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.