TIPRL — TOR signaling pathway regulator
TIPRL belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TIPRL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ER-Golgi Trafficking Protein processing & ER | ATP2B1, ATP6V1D, CAPZA2, CGGBP1, CNOT4, COPS5, CRIPT, CSTB +15 more | View in SCUBA |
| Macrophages | Mitochondrial Housekeeping Mitochondrial & OxPhos | BLOC1S2, BUD31, C14orf119, CCT5, CDC26, DGUOK, EIF2S1, GADD45GIP1 +11 more | View in SCUBA |
About the gene
| Synonyms | dJ69E11.3, MGC3794, TIP41, TIPRL1 |
|---|---|
| Chromosome | 1: 168178962-168202109 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine- protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.