SCUBA

CSTB — Cystatin B

CSTB belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CSTB's module in each cell type

Cell typeModuleShares the module with
EndothelialHypoxia Response
Stress
C1orf122, CRELD2, EFHD2, FKBP1A, HIF1A, LAPTM4B, NECTIN2, RAB13 +3 moreView in SCUBA
EnterocytesAbundant Transcript Baseline
Housekeeping
ATP5IF1, C15orf48, CALM2, CHCHD2, GHITM, KRT8, LGALS3, MPC2 +6 moreView in SCUBA
Gamma-delta T cellsT Cell Homeostasis
Housekeeping
ATP6V0E1, CALHM2, CNPY2, CSK, DAD1, FERMT3, GTF2H5, MYL12A +11 more
Glial cellsAntioxidant Stress Response
Stress
AP2S1, DYNLRB1, HSBP1, MAGED2, NDUFB11, PLPP1, PPDPF, SELENOW +1 moreView in SCUBA
Goblet cellsMucosal Antibacterial Defense
Immune function
ANXA11, B3GNT7, C15orf48, C19orf33, CLIC1, CYSTM1, ELOB, LGALS3 +8 moreView in SCUBA
Innate lymphoid cellsER-Golgi Trafficking
Protein processing & ER
ATP2B1, ATP6V1D, CAPZA2, CGGBP1, CNOT4, COPS5, CRIPT, CWC15 +15 moreView in SCUBA
Lymphatic endothelialProteasome Assembly
Protein processing & ER
ARPC2, DEGS1, GSTO1, MRPL14, PDCD5, POMP, PRELID1, PSMD7 +5 moreView in SCUBA
MacrophagesOxidative Metabolic Program
Mitochondrial & OxPhos
ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, DENND2D, EIF4EBP1 +29 moreView in SCUBA
MonocytesER Stress Response
Stress
CALR, CTNND1, HSP90B1, LPAR6, M6PR, MRPS6, PDIA6, PRDX1 +3 moreView in SCUBA
Mucosal-associated invariant T cellER & Mitochondrial Assembly
Protein processing & ER
ANAPC11, ARRDC1, ATP5MC1, COA3, DECR1, GSTK1, HINT2, MRPS26 +9 more
NeutrophilsGlycolytic Metabolism
Housekeeping
CTSD, ENO1, FAM210A, GAPDH, GRN, GSTO1, LDHA, LGALS3 +4 more

About the gene

SynonymsCST6, EPM1, PME, STFB
Chromosome21: 43772511-43776330
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Molecular functionProtease inhibitor, Thiol protease inhibitor

Function

This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.