ER-Golgi Trafficking
Gene co-expression module in Innate lymphoid cells
| Category | Protein processing & ER |
|---|---|
| Genes | 24 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 24 genes have a known function matching the annotation |
Why this annotation
This module has weak coherence, low mean expression, and very low pct positive. Nearly all genes have weak membership. Hub genes include COPS5 (COP9 signalosome subunit 5, ubiquitin/deneddylation), SAR1A (COPII vesicle formation, ER-to-Golgi trafficking), CGGBP1 (CGG-binding protein, transcription regulation), DNAJC19 (mitochondrial import chaperone), SFT2D1 (SNARE-interacting, Golgi trafficking), TIPRL (TOR signaling inhibitor), SERPINB1 (serine protease inhibitor, neutrophil/lymphocyte survival), PPP1CB (protein phosphatase 1), CNOT4 (CCR4-NOT deadenylase complex, mRNA decay), CWC15 (spliceosome), RAB1A (ER-to-Golgi vesicle trafficking), EIF4E (cap-dependent translation initiation), FUBP1 (RNA-binding, transcription), MRPS7 and MRPL54 (mitochondrial ribosomal proteins), ATP2B1 (plasma membrane Ca2+ ATPase), CSTB (cystatin B, protease inhibitor), CRIPT (PDZ domain), KRAS (RAS GTPase signaling), MRPL54. The module is very weakly coherent and combines ER/Golgi trafficking (SAR1A, SFT2D1, RAB1A), mRNA processing (CNOT4, CWC15, EIF4E, FUBP1), mitochondrial ribosome (MRPS7, MRPL54, DNAJC19), and signaling (KRAS, TIPRL, PPP1CB) genes. The positive delta_treatment signal is notable but not significant. This is a poorly defined mixed housekeeping module. The dominant theme is general cellular housekeeping/ER-Golgi trafficking.
Genes
ATP2B1, ATP6V1D, CAPZA2, CGGBP1, CNOT4, COPS5, CRIPT, CSTB, CWC15, DNAJC19, DPM1, EIF4E, FUBP1, KRAS, MRPL54, MRPS7, PPP1CB, RAB1A, SAR1A, SERPINB1, SFT2D1, TIPRL, TMSB10, ZCRB1
Most correlated modules
- Proteasome ER Proteostasis · correlation 0.93
- RNA Splicing Processing · correlation 0.92
- Mitochondrial Translation · correlation 0.92
- Pre-mRNA Splicing · correlation 0.92
- DNA Damage Response · correlation 0.91
- Endosomal Trafficking Signaling · correlation 0.91
- Mitochondrial Housekeeping · correlation 0.91
- RNA Processing & Proteostasis · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.