TMTC2 — Transmembrane O-mannosyltransferase targeting cadherins 2
TMTC2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMTC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene intronic signal Technical artifact | ASCC3, CASK, KCNQ1, LGR4, MAP3K5, MECOM, MID1, PPP1R9A +5 more | View in SCUBA |
| Smooth muscle cells | Netrin Guidance Signaling Development | GNG7, MMP23B, NTN1, PFKP, PRKAR2B, QSOX1, TYRP1 | View in SCUBA |
About the gene
| Synonyms | DKFZp762A217 |
|---|---|
| Chromosome | 12: 82686880-83134870 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Transferase |
Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.