Netrin Guidance Signaling
Gene co-expression module in Smooth muscle cells
| Category | Development |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes NTN1 (netrin-1 axon guidance/adhesion cue), GNG7 and PRKAR2B (neuronal G-protein/cAMP signaling), TMTC2 and QSOX1 (secretory/glycosylation and sulfhydryl oxidase for ECM assembly), MMP23B and TYRP1 round out a low-abundance, uniformly detected program with neural-crest/guidance flavor. Expression is very low (6.5% positive) and no subset is enriched, so this is a sparse, weakly expressed developmental/guidance program rather than a canonical SMC state. Its neighbor M114 (STMN2, CHL1, CNTN4) shares the neural adhesion/guidance theme, supporting a common neuro-developmental signaling axis rather than an artifact; PFKP (glycolysis) and QSOX1 are peripheral metabolic/secretory partners.
Genes
GNG7, MMP23B, NTN1, PFKP, PRKAR2B, QSOX1, TMTC2, TYRP1
Most correlated modules
- FOXF2 Mesenchymal Patterning · correlation 0.87
- Basement Membrane Matrix · correlation 0.82
- Growth Arrest Stress · correlation 0.80
- SMC Contractile Signaling · correlation 0.78
- Collagen-Laminin Deposition · correlation 0.76
- Notch-TGFbeta Signaling · correlation 0.73
- Matrisome Regulators · correlation 0.72
- Microfibril ECM Assembly · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.