NTN1 — Netrin 1
NTN1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NTN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Wnt-Niche Fibroblast Developmental | AHNAK, AHNAK2, AKAP12, CELF2, CYSLTR1, DPYSL3, DST, GAS6 +10 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, HMCN1, KAT2B +11 more | View in SCUBA |
| Smooth muscle cells | Netrin Guidance Signaling Development | GNG7, MMP23B, PFKP, PRKAR2B, QSOX1, TMTC2, TYRP1 | View in SCUBA |
About the gene
| Synonyms | NET1, NTN1L |
|---|---|
| Chromosome | 17: 9021510-9244000 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Apoptosis |
Function
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.