QSOX1 — Quiescin sulfhydryl oxidase 1
QSOX1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
QSOX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CCL11 Secretory Fibroblast ECM production | ANK3, ARHGAP24, CCL11, COL16A1, COL18A1, DTX4, F11R, GABRA2 +5 more | View in SCUBA |
| Macrophages | Phagocytic Endolysosomal Lysosomal & pahgocytosis | ABHD2, ACTN4, AP3S1, ARF6, ATP6V1B2, CD151, CERS2, CNIH1 +27 more | View in SCUBA |
| Smooth muscle cells | Netrin Guidance Signaling Development | GNG7, MMP23B, NTN1, PFKP, PRKAR2B, TMTC2, TYRP1 | View in SCUBA |
About the gene
| Synonyms | QSCN6 |
|---|---|
| Chromosome | 1: 180154869-180204030 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Oxidoreductase |
Function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.