TYRP1 — Tyrosinase related protein 1
TYRP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TYRP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ICC contractility Gut motility | BEX1, BTC, DES, HACD1, HSPB7, IL17B, KCNMA1, LDB3 +7 more | View in SCUBA |
| Smooth muscle cells | Netrin Guidance Signaling Development | GNG7, MMP23B, NTN1, PFKP, PRKAR2B, QSOX1, TMTC2 | View in SCUBA |
About the gene
| Synonyms | b-PROTEIN, CAS2, CATB, GP75, OCA3, TRP, TYRP |
|---|---|
| Chromosome | 9: 12685439-12710285 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Monooxygenase, Oxidoreductase |
| Biological process | Melanin biosynthesis |
Function
Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6- dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2- carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.