TOMM70 — Translocase of outer mitochondrial membrane 70
TOMM70 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TOMM70's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | ER Morphology Stress Stress | ARMC1, ARPP19, ATL3, CMPK1, CYB5B, EIF2AK1, ELAVL1, ERGIC2 +8 more | View in SCUBA |
About the gene
| Synonyms | KIAA0719, Tom70, TOMM70A |
|---|---|
| Chromosome | 3: 100363431-100401089 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Host-virus interaction |
Function
Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.