ER Morphology Stress
Gene co-expression module in Macrophages
| Category | Stress |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub ATL3 is an atlastin GTPase critical for ER tubule fusion and ER morphology. Supporting ER/secretory pathway genes: ERGIC2 (ER-Golgi intermediate compartment protein), CYB5B (ER-localized cytochrome b5), TMX4 (ER-resident thioredoxin, oxidative protein folding), MGAT2 (Golgi N-acetylglucosaminyltransferase II, glycosylation). EIF2AK1 (HRI kinase) phosphorylates eIF2alpha as part of the integrated stress response, often triggered by ER stress. ELAVL1 (HuR) stabilizes stress-response mRNAs. HDAC2 and ARPP19 add epigenetic/cell cycle context. TOMM70 (mitochondrial import receptor) and ARMC1 (mitochondrial morphology) suggest some mitochondrial involvement. The dominant theme is ER morphology and secretory pathway function, with an integrated stress response component. As a neighbor to M80 and M121 (RNA processing), the RNA-binding genes (ELAVL1, SRSF1, TSN) likely reflect shared co-expression with the RNA processing neighborhood.
Genes
ARMC1, ARPP19, ATL3, CMPK1, CYB5B, EIF2AK1, ELAVL1, ERGIC2, HDAC2, LRRC58, MGAT2, PSME3, SRSF1, TMX4, TOMM70, TSN, XPOT
Most correlated modules
- Central Carbon Metabolism · correlation 0.97
- Nuclear Pore Transport · correlation 0.96
- Glycogen Metabolism · correlation 0.96
- Autophagy Vesicular Trafficking · correlation 0.95
- mRNA Splicing Processing · correlation 0.94
- ER Protein Quality Control · correlation 0.94
- Actin Cytoskeleton Organization · correlation 0.94
- RNA Processing & Repair · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.