TTYH2 — Tweety family member 2
TTYH2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TTYH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1 +15 more | View in SCUBA |
About the gene
| Synonyms | C17orf29 |
|---|---|
| Chromosome | 17: 74213571-74262020 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Chloride channel, Ion channel |
| Biological process | Ion transport, Transport |
Function
Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.