FHL3 — Four and a half LIM domains 3
FHL3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FHL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FSCN1, GABRE +15 more | View in SCUBA |
| Gamma-delta T cells | Death Receptor Apoptosis Stress | CXCR3, GABARAPL2, LDLRAP1, LY6E, PDGFB, PLSCR3, SGSM3, SHISAL2A +4 more | |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | A2M, CD34, CISD1, FAM89A, FSCN1, GJC2, GRAP, HTRA1 +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mature Effector MAIT T cell maturation | ADD3, ANTKMT, APOBEC3G, CCL5, CXXC5, GZMK, ITGA6, ITGB2 +7 more | |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | ANTXR1, BAG2, CDH11, COL12A1, CTSB, FSTL3, HEPH, PIM1 +6 more | View in SCUBA |
About the gene
| Synonyms | SLIM2 |
|---|---|
| Chromosome | 1: 37996770-38005606 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Transcription, Transcription regulation |
Function
Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.