CXCL12 Angiogenic Chemotaxis
Gene co-expression module in Endothelial
| Category | Chemotaxis |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
CXCR4 and ACKR3 (CXCR7) are the two receptors for CXCL12/SDF-1, a key chemokine axis driving endothelial chemotaxis, angiogenesis, and homing. PGF (placental growth factor) is a VEGF family member promoting angiogenesis. FSCN1 (fascin) bundles actin in filopodia of migrating tip cells. PCDH12 is an endothelial-specific cadherin involved in vascular morphogenesis. ARHGAP18 regulates Rho GTPases during endothelial migration. SPRED2 modulates Ras/MAPK downstream of angiogenic receptors. CHST1 modifies proteoglycans affecting chemokine presentation. NID2 and LAMA4 are BM components supporting angiogenic sprouting. TNFAIP8L1 and RASSF2 link to inflammatory/apoptotic signaling. The significant inflammation upregulation in both UC and CD supports an inflammatory angiogenesis/chemotaxis program.
Genes
ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1, GABRE, GNG2, KIT, LAMA4, LXN, NETO2, NID2, PALD1, PCDH12, PGF, RASSF2, SPRED2, TNFAIP8L1, TP53I11, TSPAN15, TTYH2
Most correlated modules
- VEGF Tip Cell Signaling · correlation 0.72
- Coagulation Protease Signaling · correlation 0.62
- Inflammatory EC Activation · correlation 0.59
- Inflammatory Angiogenesis · correlation 0.56
- EC Cytoskeletal Scaffold · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.