ARHGEF7 — Rho guanine nucleotide exchange factor 7
ARHGEF7 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Rho-GTPase Migration migration & adhesion | ARHGAP18, FNBP1, HELZ, LPXN, MAP4K1, MIS18BP1, PREX1, RORA +4 more | View in SCUBA |
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, CHST1, CXCR4, FHL3, FSCN1, GABRE +15 more | View in SCUBA |
| Innate lymphoid cells | Inflammasome Activation Inflammation | ANKRD28, AP3D1, CCNH, CD55, CDC42SE1, CHD7, CHKA, CRYBG1 +19 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABHD18, AFF1, DIP2B, DNAAF9, DOCK11, EVI5, GNAQ, IL1RAP +24 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tissue Residency Regulation Tissue residence | ABCC1, ANKRD28, CA2, CDV3, CHD7, CYTIP, IL18R1, JMY +4 more |
About the gene
| Synonyms | BETA-PIX, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB |
|---|---|
| Chromosome | 13: 111114559-111305737 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Neurogenesis |
Function
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.