FSCN1 — Fascin actin-bundling protein 1
FSCN1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FSCN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TRIM28-ZNF Repression DNA/chromatin regulation | B4GALT4, EEA1, HSPA2, ISG20L2, MAP3K13, MLF1, MORN3, PABPC4 +7 more | View in SCUBA |
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, GABRE +15 more | View in SCUBA |
| Fibroblasts | Integrated Stress Response Stress | ATF4, BAIAP2, DNAJB6, EIF4A3, EIF5, HSP90AB1, HSPD1, HSPE1 +9 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Formation Valve formation | A2M, CD34, CISD1, FAM89A, FHL3, GJC2, GRAP, HTRA1 +5 more | View in SCUBA |
| Pericytes | Cytoskeletal Remodeling Cytoskeletal | ARHGAP18, F2RL3, IVNS1ABP, JUP, PASK, SEMA3F, TBCD, VWA1 | View in SCUBA |
About the gene
| Synonyms | FLJ38511, p55, SNL |
|---|---|
| Chromosome | 7: 5592816-5606655 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.