VEGFC — Vascular endothelial growth factor C
VEGFC belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VEGFC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenesis Inflammation | AZIN1, DHH, FBLN5, FILIP1L, GJA5, ITSN2, NUDT4, OCIAD2 +6 more | View in SCUBA |
About the gene
| Synonyms | VEGF-C, VRP |
|---|---|
| Chromosome | 4: 176683538-176792922 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins, Transporters |
| Molecular function | Developmental protein, Growth factor, Mitogen |
| Biological process | Angiogenesis, Differentiation |
Function
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.