AZIN1 — Antizyme inhibitor 1
AZIN1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AZIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | IL6-STAT3 Signaling Intercellular communication | ARID5A, ARL6IP1, CCDC66, CDC40, CEMIP2, CHD1, CSNK1D, EIF4G2 +13 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis Inflammation | DHH, FBLN5, FILIP1L, GJA5, ITSN2, NUDT4, OCIAD2, PIK3C2B +6 more | View in SCUBA |
| Gamma-delta T cells | Stress Negative Feedback Immune regulation | ANKRD12, CCDC186, CDKN1A, CYLD, DENND4A, DNAJB6, DUSP10, ELL +7 more | |
| Lymphatic endothelial | DNA Damage Apoptosis DNA/chromatin regulation | BAZ1A, HNRNPC, IVNS1ABP, MAPK6, OTUD4, PHLDB2, SPEN, STX3 +4 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2, LRRFIP1 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Splicing Regulation RNA processing & translation | AREG, ARHGAP9, CCNH, CLK1, DDX24, DNAJB6, IL23R, NEU1 +9 more |
About the gene
| Synonyms | OAZI, OAZIN, ODC1L |
|---|---|
| Chromosome | 8: 102826111-102893864 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Polyamine biosynthesis |
Function
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.