ITSN2 — Intersectin 2
ITSN2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITSN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators B cell maturation | ACAP2, BCL2L11, CDK13, EHMT1, FNBP1, JAK1, KMT2A, ST6GAL1 +3 more | View in SCUBA |
| CD4⁺ T cells | AKT survival signaling TCR/AP1/NFKb pathway | ABHD2, AKT1, ARL14EP, ATF7, ATP6AP1, CHD8, GNGT2, IP6K2 +10 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis Inflammation | AZIN1, DHH, FBLN5, FILIP1L, GJA5, NUDT4, OCIAD2, PIK3C2B +6 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | AEBP2, ARID1B, ATG12, ATXN2L, BRWD1, CSNK1G3, EHBP1L1, FBRS +18 more | |
| Lymphatic endothelial | ZEB1-driven EMT endothelial development | ASH1L, CUX1, ERBIN, KIF1B, MKLN1, NFAT5, NIPBL, PAFAH1B1 +7 more | View in SCUBA |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Maintenance Housekeeping | DCTN4, FAM13B, GBF1, GOLGA4, GPRIN3, HUWE1, PAFAH1B1, PPP6R3 +4 more |
About the gene
| Synonyms | KIAA1256, PRO2015, SH3D1B, SH3P18, SWA, SWAP |
|---|---|
| Chromosome | 2: 24202864-24360536 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Differentiation, Endocytosis, Host-virus interaction |
Function
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.