ZBTB32 — Zinc finger and BTB domain containing 32
ZBTB32 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZBTB32's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activated B cell B cell maturation | ARHGAP25, ARID3A, CFLAR, DUSP4, ENTPD1, MYO1F, PIK3R5, PLXNC1 +6 more | View in SCUBA |
| CD4⁺ T cells | Regulatory T cell Immune regulation | ATP1B1, EBI3, FOXP3, GADD45A, GCNT1, GTF2H5, IL1R1, IL1R2 +6 more | View in SCUBA |
About the gene
| Synonyms | FAXF, FAZF, Rog, TZFP, ZNF538 |
|---|---|
| Chromosome | 19: 35704558-35717038 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.