Activated B cell
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes (PTPN1, ARID3A, ZBTB32, THEMIS2, DUSP4, ENTPD1, PREX1, PIK3R5, ARHGAP25) are characteristic of activated/atypical memory B cells and BCR signaling regulation. ARID3A and ZBTB32 are B cell transcription factors driving age-associated/activated B-cell differentiation; THEMIS2 and DUSP4 are BCR signaling modulators. This signature reflects an activated effector B-cell state, consistent with the disease-associated (inflammation-up, remission-down) profile.
Genes
ARHGAP25, ARID3A, CFLAR, DUSP4, ENTPD1, MYO1F, PIK3R5, PLXNC1, PREX1, PTPN1, RAB31, TCTN3, THEMIS2, VOPP1, ZBTB32
Most correlated modules
- Lysosomal proteases · correlation 0.89
- Atypical memory B cell · correlation 0.88
- Tissue-resident memory B · correlation 0.88
- Cytoskeleton/motility · correlation 0.81
- TNF/NF-kB response · correlation 0.80
- B cell activation · correlation 0.78
- B cell activation · correlation 0.78
- ER/vesicle trafficking · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.