Mixed Metabolic Ambient
Gene co-expression module in CD4⁺ T cells
| Category | Technical artifact |
|---|---|
| Genes | 10 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
Small, lowly expressed mixed module. ENO2 (neuronal enolase, glycolysis), SPINK2, FABP6, FCGRT, DPYD. FABP6 and FCGRT are intestinal/epithelial associated; SPINK2 is hematopoietic progenitor. No coherent CD4 T program; appears to be low-level mixed/ambient signal with metabolic genes. Weak confidence.
Genes
DPYD, ENO2, FABP6, FCGRT, GRAP, SMURF2, SPINK2, SYNJ2BP, TNFRSF10B, ZNF891
Most correlated modules
- Activated Effector ISG · correlation 0.95
- Glycosylation & trafficking · correlation 0.84
- RNA processing · correlation 0.77
- PD-L1 checkpoint · correlation 0.74
- mRNA Splicing Factors · correlation 0.68
- Respiratory chain assembly · correlation 0.68
- Chromatin Regulation · correlation 0.64
- Cytotoxic Effector CD4 · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.