Regulatory T cell
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes are strongly associated with regulatory T cell biology: IKZF2 (Helios, Treg lineage marker), TIGIT (Treg/exhaustion co-inhibitory receptor), CD27 and RTKN2 (a Treg-enriched gene). VAV3 and STAM relate to TCR signaling. The combination of IKZF2+TIGIT+RTKN2 strongly points to a Treg/immune-regulatory program upregulated in inflamed IBD tissue (positive delta_inflammation). CD79B is a minor B-cell peripheral gene. ACTA2/DNAH8 are weakly associated and likely peripheral. The dominant signal is regulatory T cell identity.
Genes
ACTA2, APOLD1, ATP13A3, CARD16, CD27, CD79B, DNAH8, FAM184A, HS3ST3B1, IKZF2, KLHL2, RTKN2, STAM, TIGIT, VAV3, ZNF80
Most correlated modules
- IL10/cytokine signaling · correlation 0.92
- LAYN+ tissue Treg · correlation 0.90
- Activated Treg · correlation 0.90
- MAPK feedback signaling · correlation 0.87
- TCR signaling activation · correlation 0.81
- Treg regulation · correlation 0.80
- mRNA stability regulation · correlation 0.80
- Cell cycle regulators · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.