Respiratory chain assembly
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Small tight module dominated by mitochondrial respiratory chain assembly/complexes: COA6, COA4 (cytochrome c oxidase assembly), CYC1 (Complex III), VMA21 (V-ATPase assembly), PRELID3B (mito lipid transfer), plus proteasome PSMD3 and RNA Pol POLR2E. Strongly mitochondrial OxPhos; neighbor of M62 supporting OxPhos identity.
Genes
COA4, COA6, CYC1, EBNA1BP2, ERCC1, POLR2E, PRELID3B, PSMD3, VMA21
Most correlated modules
- Oxidative phosphorylation · correlation 0.94
- Glycosylation & trafficking · correlation 0.90
- PD-L1 checkpoint · correlation 0.90
- Epigenetic regulation · correlation 0.85
- Oxidative Phosphorylation · correlation 0.81
- Chaperone Proteostasis · correlation 0.78
- Activated Effector ISG · correlation 0.78
- Vesicular trafficking · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.