NF-kB activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 30 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 30 genes have a known function matching the annotation |
Why this annotation
Dominated by NF-kB pathway transcription factors (RELB, NFKB1, NFKB2, REL), survival gene BCL2A1, STAT5A, MYC, PIM3, and stress/UPR genes (CALR, NFE2L2). Clear NF-kB activation program, upregulated with inflammation. Nucleolar genes (NCL, DDX21, GNL3) reflect concurrent MYC-driven biogenesis but the identity is NF-kB.
Genes
ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A, GNL3, MRPL14, MYC, NCL, NDUFAF4, NFE2L2, NFKB1, NFKB2, NINJ1, OTUD4, PIM3, PLAGL2, RANGAP1, REL, RELB, SLC25A5, STAT5A, TMEM88, TRAF4, TTF2, TXLNG, WDR43
Most correlated modules
- Nucleotide biosynthesis · correlation 0.71
- Ribosome biogenesis · correlation 0.67
- TNF/NF-kB activation · correlation 0.65
- TCR early activation · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.