TCR signaling activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
Hubs are a heterogeneous set of signaling and metabolic genes (TNIK - a Wnt/TCR-associated kinase important in Th17, DAPP1 - BCR/TCR adaptor, NUMA1, CORO1B - actin/cytoskeleton in T cell migration, FCMR, SETD2 chromatin). Lipid metabolism genes (UGCG, FAAH2, ECI1, THEM4, ACOT-like) are also present. No single dominant immune program; the strongest coherent thread is TCR/signaling-associated activation with metabolic remodeling. Given TNIK/DAPP1/CORO1B and the inflammation association, a general T-cell activation signaling module is most defensible.
Genes
CNST, CORO1B, DAPP1, ECI1, FAAH2, FCMR, GPCPD1, KLHL24, MLLT3, NUMA1, PLCL1, RIC3, SETD2, SGTB, THEM4, TNIK, UGCG
Most correlated modules
- Regulatory T cell · correlation 0.81
- IL10/cytokine signaling · correlation 0.78
- Cell cycle regulators · correlation 0.72
- Transcription/RNA processing · correlation 0.68
- Leukocyte adhesion signaling · correlation 0.67
- LAYN+ tissue Treg · correlation 0.65
- Treg regulation · correlation 0.64
- Post-transcriptional regulation · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.