T cell co-receptors
Gene co-expression module in CD4⁺ T cells
| Category | T cell development |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes THEMIS (T-cell selection/TCR signaling), CD96, CD200R1, GPR171, JAML, and CD40LG indicate a T cell activation/co-receptor program. CD40LG is the key B cell help molecule and CD200R1/GPR171 are immune regulatory receptors. The mix of co-stimulatory/co-inhibitory receptors and CD40LG suggests a helper/regulatory CD4 T cell state. CD40LG strongest functional anchor points toward B cell help, but module is broadly a T-cell co-receptor/activation signature.
Genes
AGO4, ARRB2, CAPG, CD200R1, CD40LG, CD96, EMB, FKBP11, GAB3, GOLGA8B, GPR171, JAML, LMO4, MGAT4A, MYO1F, RBL2, RPS6KA3, SLK, STOM, THEMIS, TNFSF14, TSEN54
Most correlated modules
- Gamma-delta T cell · correlation 0.84
- Th17 lineage · correlation 0.80
- Cytotoxic Effector CD4 · correlation 0.78
- Th17/MAIT type-17 · correlation 0.73
- Cell motility/adhesion · correlation 0.72
- Cytokine signaling · correlation 0.69
- Immune regulation · correlation 0.68
- Inflammatory activation · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.