TCR signaling
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include TCR-proximal signaling components: TRAT1 (TRIM, stabilizes TCR-CD3), SOS1 (RAS GEF downstream of TCR), CAMK4 (Ca2+/calmodulin kinase in T cell activation), PTGER4, CHD7. PLAC8, ADA2, ANK3 also present. The combination of TRAT1, SOS1, CAMK4 points to a TCR signaling / naive-resting T cell program. Uniform low expression, positive remission deltas suggest restful state. Best labeled as TCR signaling.
Genes
ACVR1C, ADA2, ANK3, CAMK4, CHD7, GCLM, GNAO1, MPP7, NME4, OGFRL1, PCSK5, PLAC8, PTGER4, RNF144A, RRAS2, SCML4, SNTB1, SORBS3, SORL1, SOS1, TC2N, TMEM71, TRAT1, WWC2
Most correlated modules
- Resting memory T cell · correlation 0.91
- T cell quiescence · correlation 0.83
- Ribosomal proteins · correlation 0.80
- Cytotoxic effector · correlation 0.72
- Cytokine signaling · correlation 0.68
- Unfolded Protein Response · correlation 0.68
- Naive T cell · correlation 0.67
- T cell signaling · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.