Epigenetic regulation
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Strong module anchored by TET2 (core, DNA demethylase), ZEB1, JARID2, ARID1B (chromatin remodeling), TMPO, VDR, UBE3A. These are epigenetic/transcriptional regulators of T cell differentiation. TET2 and JARID2/ARID1B are key chromatin regulators in CD4 T cell fate. Clear DNA/chromatin regulation program.
Genes
AFF4, ARID1B, CTSA, DGKH, FUBP1, JARID2, PDCD6, SYNCRIP, TET2, TMPO, TSPAN5, UBE3A, VDR, VEZT, ZEB1
Most correlated modules
- Oxidative phosphorylation · correlation 0.90
- PD-L1 checkpoint · correlation 0.88
- Chromatin regulation · correlation 0.87
- Respiratory chain assembly · correlation 0.85
- RNA & Chromatin Regulation · correlation 0.84
- Glycosylation & trafficking · correlation 0.84
- Chaperone Proteostasis · correlation 0.79
- Chromatin Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.