T cell signaling
Gene co-expression module in CD4⁺ T cells
| Category | T cell development |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Small module with TESPA1 (thymocyte expressed, TCR signaling), AFF3 (lymphoid transcription factor, autoimmune locus), ZFYVE9/SARA (TGF-beta/SMAD signaling), RASGRF2 (TCR-induced Ras signaling), PELI2 (TLR/IL-1 signaling). Genes converge on T-cell signaling/development with TGF-beta and TCR components. Best characterized as a T-cell signaling/development program.
Genes
AFF3, PELI2, RASGRF2, RNF130, TESPA1, TRIM44, ZFYVE9, ZNF506
Most correlated modules
- Naive T cell · correlation 0.88
- T cell quiescence · correlation 0.72
- TCR signaling · correlation 0.65
- Naive resting T cell · correlation 0.64
- Immediate early activation · correlation 0.59
- Hypoxia metabolic stress · correlation 0.57
- Proliferation/differentiation · correlation 0.55
- Naive T cell · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.