Cytokine receptor signaling
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include ID2 (transcriptional regulator of T cell differentiation), ZFP36L1 (RNA-binding AU-rich element protein controlling T cell quiescence), and cytokine receptor genes IL18RAP and IL15RA, which mark effector/memory CD4 T cell responsiveness to innate cytokines. PERP, C6orf62, MMD, C21orf91 are more general. The combination of ID2, IL18RAP, IL15RA and ZFP36L1 points to an innate cytokine-responsive effector T cell state rather than a clean single pathway. Module is moderate coherence and uniform expression, consistent with a CD4 T cell activation/cytokine-sensing program.
Genes
C21orf91, C6orf62, DDX3X, HNRNPH1, ID2, IL15RA, IL18RAP, MMD, PERP, ZFP36L1
Most correlated modules
- Th17/MAIT type-17 · correlation 0.69
- Gamma-delta T cell · correlation 0.68
- Cytokine signaling · correlation 0.68
- T cell co-receptors · correlation 0.65
- Effector activation NFkB · correlation 0.65
- Immune regulation · correlation 0.63
- Immediate Early AP-1 · correlation 0.62
- Th17 lineage · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.