ER stress UPR
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
Hubs are ER/secretory and protein folding genes (MANF, P4HB, DNAJB11, CRELD2, TMED2, SSR-associated), glycolysis (TPI1), and cytoskeletal/actin (DSTN, VASP). Strong ER stress/UPR and protein-processing signature dominates the module identity.
Genes
CCT2, CDK2AP2, CRELD2, DDX39A, DNAJB11, DSTN, EIF5A, GPSM3, GTF3A, MANF, METTL9, MFSD10, MYDGF, P4HB, PRDX1, TMED2, TPI1, VASP
Most correlated modules
- Actin Cytoskeleton · correlation 0.77
- Respiratory chain assembly · correlation 0.69
- Chaperone Proteostasis · correlation 0.68
- Nucleotide biosynthesis · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.