Regulatory T cell
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Contains FOXP3 (master Treg transcription factor), EBI3 (subunit of IL-35/IL-27, Treg suppressive cytokine), IL1R1 and IL1R2 (IL-1 receptors, IL1R2 a decoy receptor marker of activated/inflamed Tregs), ZBTB32, GADD45A. This is clearly an inflammation-associated regulatory T cell (effector/activated Treg) signature, strongly induced in UC/CD inflammation and reduced with treatment. Neighbors M86 (FOXO1/IL10 immune regulation) reinforce a Treg/immune regulation neighborhood.
Genes
ATP1B1, EBI3, FOXP3, GADD45A, GCNT1, GTF2H5, IL1R1, IL1R2, IPCEF1, MAP1LC3A, POU2F2, RPA3, SYNGR2, TFRC, ZBTB32
Most correlated modules
- Immune Regulation · correlation 0.90
- Lipid Metabolism · correlation 0.87
- Activated Treg · correlation 0.85
- T cell activation · correlation 0.83
- Mitochondrial Translation · correlation 0.82
- OxPhos & proteasome · correlation 0.82
- Oxidative Phosphorylation · correlation 0.80
- CD4 Lineage Identity · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.