Transcriptional regulation
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes are a mix of transcriptional/chromatin regulators (JMJD1C, NR1D2, PHF20, IVNS1ABP), RNA processing factors (CWC25, KRR1, EIF2A), and signaling/metabolic genes (CCNH, PDCD4, RPS6KA5, LPIN2). There is no single dominant program; the module appears to capture a broadly-expressed transcriptional/RNA regulatory housekeeping signature with circadian (NR1D2) and chromatin (JMJD1C, PHF20) components. Uniform low-moderate expression, no clear contamination. CCNH is part of the CDK-activating kinase. Given the heterogeneity but enrichment in nuclear transcriptional regulators, best characterized as a general DNA/chromatin regulatory module. CD inflammation association is modest.
Genes
CCNH, CWC25, DYNLL2, EIF2A, GOLGB1, IVNS1ABP, JMJD1C, KRR1, LPIN2, NR1D2, ODF2L, PDCD4, PGGHG, PHF20, RNF149, RPS6KA5, ST3GAL1
Most correlated modules
- mRNA Splicing Factors · correlation 0.75
- Cytotoxic Effector CD4 · correlation 0.66
- Chromatin Regulation · correlation 0.65
- Activated Effector ISG · correlation 0.64
- Mixed Metabolic Ambient · correlation 0.61
- T cell co-receptors · correlation 0.58
- Th17/MAIT type-17 · correlation 0.46
- mRNA Splicing Processing · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.