Ribosome biogenesis
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 26 genes have a known function matching the annotation |
Why this annotation
Hubs are ribosome biogenesis/nucleolar factors (RSL1D1, RSL24D1, NPM1, NIP7, C1QBP), glycolysis (LDHA), nucleotide metabolism (APRT, IMPDH2), and MYC-target proliferation genes (YBX1, HNRNPA1). This is a MYC-driven anabolic/ribosome-biogenesis proliferation module of activated T cells.
Genes
APEX1, APRT, C1QBP, CCDC59, HNRNPA1, IMPDH2, LBH, LDHA, LSM5, MRPL32, MRPS33, NDFIP1, NDUFB9, NIP7, NPM1, PPIA, RPL36AL, RSL1D1, RSL24D1, SEC62, SLC25A3, SMAP2, SSR4, TFAM, TRMT6, YBX1
Most correlated modules
- Nucleotide biosynthesis · correlation 0.75
- NF-kB activation · correlation 0.67
- Translation machinery · correlation 0.65
- Leukocyte adhesion signaling · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.