Chaperone Proteostasis
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
The top hub genes are dominated by the CCT/TRiC chaperonin complex (CCT4, CCT3, CCT5) together with co-chaperones and stress proteins (HSPB1, STIP1, NUDC). Additional members include protein folding/quality control (UBE2D3), redox stress (SOD1, SELENOF), and RNA-binding proteins (FXR1, HNRNPH3, MAGOH). The signature centers on cytosolic chaperone-mediated protein folding/proteostasis. Uniform expression across subsets with no lineage-specific enrichment argues against contamination. The clear chaperonin core (CCT3/4/5) plus HSPB1/STIP1 makes a protein folding/chaperone program the best label. Increased with inflammation, consistent with a proteostasis stress response.
Genes
BANF1, CCT3, CCT4, CCT5, FXR1, HNRNPH3, HSPB1, MAGOH, NUDC, RHEB, SELENOF, SOD1, STIP1, TOP1, UBE2D3, ZC3H15
Most correlated modules
- Epigenetic regulation · correlation 0.79
- Oxidative phosphorylation · correlation 0.79
- Respiratory chain assembly · correlation 0.78
- OxPhos & redox · correlation 0.75
- Vesicular trafficking · correlation 0.74
- T cell activation · correlation 0.74
- PD-L1 checkpoint · correlation 0.73
- Chromatin regulation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.