Tissue residence
Gene co-expression module in CD8⁺ T cells
| Category | Gut residence |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
The module contains KRT86 and KRT81 (hair-type keratins), which are highly atypical for CD8 T cells and suggest minor contamination or an artifact. KIR2DL4 is an NK/NKT receptor. FAM3C and NBL1 relate to TGF-β/BMP signaling. HTRA1 is a secreted serine protease. PTPN6 (SHP-1) is an immune phosphatase. PLPP1 and AFAP1L2 link to cytoskeletal/lipid programs. The combination of structural keratins with immune phosphatase and NK receptor genes in a low-expression, low-detection module suggests a poorly defined or contaminated minor cell state. KRT81/KRT86 could reflect contaminating epithelial or follicular cells.
Genes
AFAP1L2, FAM3C, HTRA1, KIR2DL4, KRT81, KRT86, NBL1, PLPP1, PTPN6, UBE2F
Most correlated modules
- Cytotoxic Exhausted CD8 · correlation 0.80
- Cytotoxic Gut Effector · correlation 0.76
- TCR Activation & Modulation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.