Cytotoxic Gut Effector
Gene co-expression module in CD8⁺ T cells
| Category | cytotoxicity |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
GNLY (granulysin) and GZMA (granzyme A) are hallmark cytotoxic effector molecules. IL2RB (CD122) marks NK and cytotoxic T cells. CD63 is a lysosomal marker associated with degranulation. ITGB7 is the gut-homing integrin (pairs with ITGA4 for MAdCAM-1 binding), placing these cells in a gut-residence context. CSF1 can be produced by activated T cells. CCND2 may reflect a proliferating subset. CEBPB has weak membership and may be noise. Overall this module marks cytotoxic effector CD8 T cells with gut-homing features.
Genes
ATP8B4, CCND2, CD63, CEBPB, CSF1, CTSA, GNLY, GNPTAB, GZMA, IL2RB, ITGB7, TBCD
Most correlated modules
- Cytotoxic Exhausted CD8 · correlation 0.81
- TCR Proximal Signaling · correlation 0.80
- TCR Activation & Modulation · correlation 0.79
- Tissue residence · correlation 0.76
- Terminal Exhaustion · correlation 0.71
- T cell Immune Tolerance · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.