NBL1 — NBL1, DAN family BMP antagonist
NBL1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NBL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Gamma-delta T cell Cell contamination | ABHD15, ANKRD28, APOBR, CLIC3, CLIC5, EGLN3, ELOVL6, GLO1 +9 more | View in SCUBA |
| CD8⁺ T cells | Tissue residence Gut residence | AFAP1L2, FAM3C, HTRA1, KIR2DL4, KRT81, KRT86, PLPP1, PTPN6 +1 more | View in SCUBA |
| Fibroblasts | Metabolic Homeostasis Housekeeping | ADH5, ALDH2, ATP2B1, ISCU, NLGN4X, PGM1, PKIG, RAB7A +4 more | View in SCUBA |
| Gamma-delta T cells | Gut-homing Residence Tissue residence | ADAM28, ASB2, ATP8B4, CAPG, CCR9, CD101, CD9, DAPK2 +8 more | |
| Goblet cells | Secreted Antimicrobials Immune function | FAM3D, IFI6, IGFBP2, KLK11, KLK12, NOXO1, PCSK1, REG1A +6 more | View in SCUBA |
| Pericytes | BMP-Stromal Signaling Developmental | BMP4, CXCL14, F3, MMP2, PDGFRA, POSTN, TMEM176A, TMEM176B | View in SCUBA |
| Smooth muscle cells | Matrisome Regulators ECM remodeling | ITM2C, LPP, LUM, PMP22, S100A13, TCEAL4, TIMP2, TMEM176B +1 more | View in SCUBA |
About the gene
| Synonyms | D1S1733E, DAN, DAND1, NB, NO3 |
|---|---|
| Chromosome | 1: 19596979-19658456 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
Function
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.