UBE2F — Ubiquitin conjugating enzyme E2 F (putative)
UBE2F belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2F's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA splicing RNA processing | ANAPC5, C11orf58, C1orf43, DDX46, DNAJC7, HSPA4, LSM14A, LUC7L3 +8 more | View in SCUBA |
| CD8⁺ T cells | Tissue residence Gut residence | AFAP1L2, FAM3C, HTRA1, KIR2DL4, KRT81, KRT86, NBL1, PLPP1 +1 more | View in SCUBA |
| Endothelial | Mitochondrial Metabolic Stress Mitochondrial & OxPhos | AFAP1, DHRS7B, LDHA, MCUR1, MRPL9, NDUFA8, NUCB2, OAZ3 +3 more | View in SCUBA |
| Innate lymphoid cells | Glycolysis & OxPhos Metabolism | ANXA7, ARF3, ATP5MC3, CD320, CD74, CNBP, COX6A1, COX6B1 +10 more | View in SCUBA |
| Macrophages | Immunoproteasome Induction Inflammatory | CBR1, DAPP1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2 +12 more | View in SCUBA |
| Natural Killer cells | Innate Sensing NK Regulation Immune regulation | ADRB2, DTHD1, FCRL6, LFNG, LIMD2, PLEK, PRR5L, PYHIN1 +1 more | View in SCUBA |
About the gene
| Synonyms | NCE2 |
|---|---|
| Chromosome | 2: 237966827-238042782 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex. (Microbial infection) Following infection by HIV-1 virus, participates to HIV-1 Vif protein-mediated ubiquitination and degradation of APOBEC3G by mediating neddylation of cullin-5 (CUL5)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.